Application-Centric Provisioning of Virtual Security Network Functions

Network Function Virtualization (NFV) enables flexible implementation and provisioning of network functions as virtual machines running on commodity servers. Due to the availability of multiple hosting servers, such network functions (also called Virtual Network Functions (VNFs)) can be placed where they are actually needed, dynamically migrated, duplicated, or deleted according to the current network requirements. However, the placement of VNFs within the physical network is one of the main challenges in the NFV domain as it has a critical impact on the performance of the network. In this work we focus on efficient placement of Virtual Security Network Functions (VSNFs), i.e. the placement of virtual network functions whose purpose is to prevent or mitigate network security threats. In this regard, we tackle the placement problem not only considering performance optimization aspects, but also trying to find solutions that are consistent from the security viewpoint. Specifically, the main contribution of this paper is the formulation of the placement problem by taking into account both Security and Quality of Service (QoS) requirements of user applications

Tennison: A Distributed SDN Framework for Scalable Network Security

Despite the relative maturity of the Internet, the computer networks of today are still susceptible to attack. The necessary distributed nature of networks for wide area connectivity has traditionally led to high cost and complexity in designing and implementing secure networks. With the introduction of software-defined networks (SDNs) and network functions virtualization, there are opportunities for efficient network threat detection and protection. SDN's global view provides a means of monitoring and defense across the entire network. However, current SDN-based security systems are limited by a centralized framework that introduces significant control plane overhead, leading to the saturation of vital control links. In this paper, we introduce TENNISON, a novel distributed SDN security framework that combines the efficiency of SDN control and monitoring with the resilience and scalability of a distributed system. TENNISON offers effective and proportionate monitoring and remediation, compatibility with widely available networking hardware, support for legacy networks, and a modular and extensible distributed design. We demonstrate the effectiveness and capabilities of the TENNISON framework through the use of four attack scenarios. These highlight multiple levels of monitoring, rapid detection, and remediation, and provide a unique insight into the impact of multiple controllers on network attack detection at scale

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin